Chimerism Testing
Overview
Chimerism genetic testing is used to monitor the success of haemopoietic stem cell transplantation (HSCT) by evaluating the ratio of donor and recipient DNA in the recipient's blood or bone marrow.
This guides treatment to help prevent engraftment failure, to maximise graft-versus-tumour effect and to minimise opportunistic infection and graft-versus-host disease.
Flow sorted chimerism analysis of peripheral blood can be used to monitor T-cell, B-cell and myeloid lineage specific engraftment upon request.
Category
Cost
Billing is to the referring hospital.
Contacts
Jackie Challis and Sara Cronin
Phone: (03) 8341 6280
Specimen Requirements
EDTA blood or bone marrow:
Less than 12 months of age: 1ml
Greater than 12 months: 2-5ml
Flow Sorted Chimerism: 5-10ml
Notes
New referrals require a genotyping workup. This requires pre-transplant samples from both recipient and donor.
Flow sorted chimerism testing must be booked at least one week in advance.