Interphase Fluorescent in situ Hybridisation or FISH, can determine if a pregnancy is at risk of having one of the common trisomies, such as Down syndrome (trisomy 21).
Targeting uncultured cells, FISH can provide:
- rapid results (24-48hrs)
- is useful in the investigation of mosaicism
- can detect Di George / velocardiofacial syndrome (VCFS) microdeletion.
Interphase FISH is always followed up with either a conventional karyotype or a molecular karyotype depending on the clinical indication and the FISH result obtained.